Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones.
نویسندگان
چکیده
Primary amino acids are found to be good enantioselective catalysts for the direct asymmetric Mannich reaction between 2-amino acetophenone and aldehydes. The 2-aryl-2,3-dihydro-4-quinoline products are obtained in moderate to good yields and good to high enantioselectivities with 10 mol% of the primary amino acid catalyst under mild reaction conditions.
منابع مشابه
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 48 شماره
صفحات -
تاریخ انتشار 2014